Abstract：A 34-year-old female patient received an intramuscular injection of compound amionpyrine antipyrine barbitone injection for acute upper respiratory infection and fever. Eight hours after medication, the patient developed deep yellow urine followed by fatigue, anorexia, and yellowish skin. Laboratory tests showed alanine aminotransferase (ALT) 764-U/L, aspartate aminotransferase (AST) 211-U/L, alkaline phosphatase (ALP） 280-U/L, gamma-glutamyltransferase (γ-GT) 861-U/L, total bilirubin (TBil） 72.0-μmol/L, direct bilirubin (DBil） 61.3-μmol/L, and indirect bilirubin (IBil)10.7-μmol/L. The patient was diagnosed as having drug-induced liver injury, which might be related to compound amionpyrine antipyrine barbitone injection. Therapy with liver-protective drugs was given immediately. Sixteen days later, her jaundice subsided. The laboratory tests showed ALT 58-U/L, AST 34-U/L, ALP 237-U/L, γ-GT 345 U/L, TBil 26.0-μmol/L, and DBil 13.1-μmol/L.
唐洁，罗丽，王瑞，刘智慧. 复方氨林巴比妥注射液致肝损伤[J]. 药物不良反应杂志, 2020, 22(7): 434-435.
Tang Jie, Luo Li, Wang Rui, Liu Zhihui. Liver injury due to compound aminopyrine antipyrine barbitone injection. Adverse Drug Reactions Journal, 2020, 22(7): 434-435.
