Abstract：A 52-year-old man receive IM phenobarbital sodium 0.1 g and IM atropine sulfate 0.5 mg thirty minutes before surgery for mixed hemorrhoids circumcision. One day later, he developed erythema and blister with itch on his thigh, sole, and the back of the hand, as well as red swelling with itch on his pudendum. Three days later, he developed sharp pain on the sole. Fixed drug eruption was diagnosed. The patient was administered an IV injection of 25% glucose 20 ml plus calcium gluconate 20 ml, an IV infusion of 5% glucose and sodium chloride 250 ml plus dexamethasone 10 mg, oral loratadine 10 mg once daily.At the same time,toptical calamine lotion was applied to his affected part. Ten days later, his symptoms disappeared, but pigmentation remained in the area of eruption.