Department of Pharmacy, the First Affiliated Hospital of Soochow University, Suzhou 215006, China; Department of Pharmacy, Suzhou BenQ Medical Centre, Suzhou 215011, China
Abstract：A 76-year-old female patient received one perindopril and indapamide tablet (containing perindopril 4.00 mg and indapamide 1.25 mg in each tablet) once daily for hypertension. Her blood pressure was well controlled. One month later, the patient was admitted to hospital for hyperglycemia. On day 2 of admission, the patient developed fever, with the highest body temperature of 38.4 ℃. Laboratory tests showed that her white blood cell count(WBC) was 1.7×109/L and neutrophils count was 0.38×109/L, which was considered to be related to perindopril and indapamide. Then perindopril and indapamide was discontinued and replaced by amlodipine besylate. And recombinant human granulocyte colony stimulating factor, leucogen, vitamin B4, and anti-infective drugs were also given. On the second day of treatment, the WBC was 6.0×109/L and neutrophils count was 4.05×109/L. The patient′s body temperature returned to normal on day 6 of admission and her WBC, neutrophils count, blood glucose, and blood pressure were 6.2×109/L, 4.55×109/L, 6.7 mmol/L, and 128/79 mmHg, respectively on day 8.
