Abstract：With the gradual improvement of people′s awareness of medication safety, drug interaction has become a hot topic in the field of medicine. However, there are still some misunderstandings about drug interactions and incompatibility, drug interactions and adverse drug reactions (ADR), the incidence of drug interactions, the clinical significance of case reports, and how to scientifically judge the clinical significance of drug interactions. Drug interactions refer to the pharmacokinetic or pharmacodynamic interactions of 2 or more drugs within the body, involving in drug absorption, distribution, metabolism, excretion, pharmacodynamics, pharmacogenomics, and etc. Compatibility refers to the changes of physical and chemical properties of 2 or more drugs in the same premixed container during the in vitro mixing process, the existence of physical incompatibility or chemical instability. Physical incompatibility and/or chemical instability are collectively referred to as incompatibility. Adverse drug interactions are not ADR. In clinical practice, attention should be paid to drug interactions with clinical significance, and contraindicated drug combinations should be actively avoided. On the premise of careful monitoring, some drugs with clinical significant interactions could also be used together. Due to the different criteria for judging drug interactions with clinical significance, it is not possible to get a generally accepted incidence of drug interactions at present. Case reports on drug interactions are important risk signals. Independent case reports of the same group of drugs have more reference value, whic
刘治军. 关于药物相互作用几个问题的思考[J]. 药物不良反应杂志, 2019, 21(6): 401-405.
Liu Zhijun. Thoughts on several problems of drug interactions. Adverse Drug Reactions Journal, 2019, 21(6): 401-405.
