Abstract：ObjectiveTo understand the incidences of adverse reactions on cognition, language, and bone metabolism related to 8 commonly used antiepileptic drugs in China using SIDER database.MethodsThe integrated incidences of adverse reactions on cognition, language, and bone metabolism related to 8 commonly used antiepileptic drugs (carbamazepine, oxcarbazepine, valproate, clonazepam, lamotrigine, levetiracetam, topiramate, and zonisamide) marketed in China was searched in the SIDER database.ResultsThe main drugs that affected cognition were topiramate and valproate. The incidences of memory impairment caused by topiramate and abnormal thinking related to valproate were 1.2%-10.8% and 6.0%, respectively. Topiramate was the main drug that affected language. The incidences of dysarthria and speech disorder caused by topiramate were 1.6%-6.2% and 1.0%-16.8%, respectively. The main antiepileptic drugs that affected bone metabolism were carbamazepine, oxcarbazepine, and valproate. But there was no incidence information because of the limited small amount of literature reports after marketing.ConclusionsThe results of data analysis in this database indicate that different antiepileptic drugs have different effects on cognitive function, language function and bone metabolism, and the frequency of adverse reactions is different. The clinical use of antiepileptic drugs needs to weigh the advantages and disadvantages according to the specific situation of patients.
傅征然, 王晓玲, 方方. 基于药物副作用SIDER数据库的抗癫痫药相关认知、语言及骨代谢不良反应分析[J]. 药物不良反应杂志, 2019, 21(6): 431-434.
Fu Zhengran, Wang Xiaoling, Fang Fang. Analysis of adverse reactions on cognition, language, and bone metabolism of antiepileptic drugs based on Side Effect Resource Database (SIDER). Adverse Drug Reactions Journal, 2019, 21(6): 431-434.
