Epidermolysis bullosa due to compound aminopyrine phenacetin tablets
Department of Dermatology, the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guizhou Province, Guiyang 550001, China
Abstract：A 51-year-old male patient took by himself oral compound aminopyrine phenacetin tablets (each tablet containing aminopyrine 150 mg, phenacetin 150 mg, caffeine 50 mg, and phenobarbital 15 mg) 2 tablets twice daily for headache. On the second day, the patient developed erythematous rash all over the body, accompanied by obvious itching and pain. Then the compound aminopyrine phenacetin tablets were stopped. On the third day, some of the macula fused into a piece, on which different sizes of loose blisters or bullae appeared. And erosion occurred at the junction of the skin and mucous of the mouth and genitals. Intravenous infusions of methylprednisolone and calcium gluconate injection, oral ebastine tablets and ketotifen fumarate tablets, and skin care were given. Six days later, his rash became lighter, most of the blisters and bullae dried up and scabbed. The dose of methylprednisolone was gradually reduced. Eleven days later, the erythema obviously improved, blisters and bullae dried up, and flaky desquamation on the epidermis occurred. Intravenous infusion of methylprednisolone was changed to oral prednisolone (20 mg/d). Thirteen days later, the rash subsided basically.
