Abstract：A 71-year-old male patient, who was admitted to hospital for hypertension and coronary artery heart disease, received an IV infusion of Xuesaitong for injection 800 mg dissolved in 250 ml of 0.9% sodium chloride injection once daily. His liver function was normal before treatment. On day 3 of treatment, the patient developed anorexia, epigastric discomfort, and rash. Laboratory tests showed that the alanine aminotransferase (ALT) was 490 U/L, aspartate aminotransferase (AST) was 657 U/L, total bilirubin (TBil) was 33.4 μmol/L, direct bilirubin (DBil) was 10.3 μmol/L, and alkaline phosphatase (ALP) was 51 U/L. The next day, the patient developed jaundice. The laboratory tests showed ALT 2 597 U/L, AST 2 647 U/L, TBil 74.6 μmol/L, DBil 24.3 μmol/L, ALP 58 U/L, prothrombin activity (PTA) 20%, and international normalized ratio 2.4. It was diagnosed as severe liver injury and was related to Xuesaitong for injection. The drug was stopped and liver-protective treatments such as polyene phosphatidylcholine injection and isoglycyrrhizic acid magnesium injection were given. One week later, the patients′ liver function improved (ALT 785 U/L, AST 653 U/L, TBil 46.0 μmol/L, ALP 44 U/L, and PTA 42%). He was transferred to another hospital. At 7 days of follow-up, the rash disappeared and laboratory tests showed ALT 433 U/L, AST 372 U/L, TBIL 35.2 μmol/L, DBIL 10.1 μmol/L, and ALP 48 U/L. No follow-up was continued after then.
王冰， 孙晓妍， 李进峰， 张媛. 注射用血塞通致严重肝损伤[J]. 药物不良反应杂志, 2020, 22(2): 115-117.
Wang Bing, Sun Xiaoyan, Li Jinfeng, Zhang Yuan. Severe hepatic injury caused by Xuesaitong for injection(注射用血塞通). Adverse Drug Reactions Journal, 2020, 22(2): 115-117.
2020, Vol. 22 
