Abstract：Three patients with epilepsy (patient 1, a 60-year-old female with a history of heart disease; patient 2, a 29-year-old male; patient 3, an 18-year-old male) received oxcarbazepine orally for epileptic seizures (patient 1 received 0.3 g twice daily; patient 20.45 g twice daily; patient 3-0.6 g twice daily). Intermittent syncope or palpitations occurred in patient 1, 2, and 3 on day 4, 5, and 1 after medications, respectively. All 3 patients showed arrhythmias in electrocardiograms. Patient 1 developed atrial fibrillation, cardiac arrest, degree III sinoatrial block, degree II type II atrioventricular block; patient 2 and 3 deve- loped different degrees of atrioventricular block. Above-mentioned arrhythmias were considered to be cardiotoxicity caused by oxcarbazepine. In patient 1, the number of syncope was reduced from 2 to 3 times per day to 1 time per day after 3 days of oxcarbazepine withdrawal, but the electrocardiogram still showed degree II type II atrioventricular block. Then no syncope recurred after implantation of heart pacemaker. In patient 2, no syncope recurred after 5 days of oxcarbazepine withdrawal. In patient 3, no palpitations recurred after reduction of oxcarbazepine to 0.45 g twice daily and addition of other antiepileptic drugs for 2 days.
褚敏，刘爱华. 奥卡西平致癫痫患者心脏毒性反应3例[J]. 药物不良反应杂志, 2020, 22(4): 262-264.
Chu Min, Liu Aihua. Cardiotoxicity due to oxcarbazepine in 3 patients with epilepsy Chu Min, Liu Aihua. Adverse Drug Reactions Journal, 2020, 22(4): 262-264.
