Rashes caused by arbidol in a patient with novel coronavirus pneumonia
Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People′s Hospital, Affiliated Hospital of University of Electronic Science and Technology, Personalized Drug Therapy Key Laboratory of Sichuan Province, Chengdu 610072, China; School of Medicine, University of Electronic Science and Technology, Sichuan Province, Chengdu 610054, China; Department of Pharmacy, Ganzi Tibetan Autonomous Prefecture People′s Hospital, Sichuan Province, Kangding 626000, China
Abstract：A 50-year-old male patient with agitated depression and hyperlipemia received oral amoxicillin and clavulanate potassium 0.5 g once daily and 2 lopinavir and ritonavir tablets twice daily for novel coronavirus infection, based on previous drugs including quetiapine, clonazepam, and atorvastatin calcium. After 3 days, lopinavir and ritonavir was changed to oral arbidol 200-mg, thrice daily due to suspicious drug interaction. After taking arbidol for 3 days, the patient developed red papules on the whole body. Considering that it might be related to amoxicillin and clavulanate potassium, the drug was stopped and loratadine was given. But the rashes were aggravated. Considering that the drug eruption was caused by arbidol, arbidol was discontinued and the rashes subsided in a large area the next day. Then vitamin C injection, calcium gluconate injection, and ribavirin were added. After 5 days, the rashes subsided completely. After 17 days, the patient recovered from pneumonia.
