Abstract：A 56-year-old male patient purchased Shiduqing capsules by himself and took the drug orally 1.5 g thrice daily for pruritus and rash. After 7 days of administration, the patient developed yellow urine, abdominal distension, and yellowish skin. Laboratory tests showed alanine aminotransferase (ALT) 1-871-U/L, aspartate aminotransferase (AST) 1-502-U/L, alkaline phosphatase (ALP) 222-U/L, total bilirubin (TBil) 260.6-μmol/L, and direct bilirubin (DBil) 187.7-μmol/L. Viral hepatitis, autoimmune liver disease, and intra and extrahepatic space-occupying lesions were excluded by virological detection of hepatitis, autoantibody examination, and imaging examination. Liver injury caused by Shiduqing capsules was considered. Then Shiduqing capsules were discontinued and magnesium isoglycyrrhizinate injection and Shuganning injection(舒肝宁注射液) were given by intravenous infusion. Twenty-eight days later, the patient′s symptoms were improved significantly, and laboratory tests showed ALT 56-U/L, AST 65-U/L, TBil 68.9-μmol/L, and DBil 51.5-μmol/L. It was considered that the liver injury was related to the component of densefruit pittany root-bark (Cortex Dictamni) in Shiduqing capsules.
