Abstract：A 69-year-old male patient was given pituitrin 24 U dissolved in 0.9% sodium injection for continuous intravenous pump once per 12-hours for alcoholic cirrhosis complicated by upper gastrointestinal hemorrhage. At the same time, omeprazole, octreotide, hemocoagulase, plasma, and symptomatic and supportive treatments were given conventionally. On the second day, the patient developed tongue swelling. Considering that it might be related to therapeutic drugs, intravenous injection of dexamethasone 5-mg and intramuscular injection of promethazine 25-mg were given. Due to the improvement of bleeding symptoms, pituitrin was stopped and other drugs continued to be used. Eight days later, black stool recurred in the patient and pituitrin was given again. The next day, the patient had tongue swelling again, which was improved after the same treatments. The patient′s tongue swelling was considered as angioedema caused by pituitrin.
