Clinical cases analysis and literature review of granulomatous mastitis induced by antipsychotics
Department of Pharmacy, Chengdu Women′s and Children′s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China; Department of Breast, Chengdu Women′s and Children′s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China
Abstract：Objective To explore the clinical characteristics of granulomatous mastitis （GM）induced by antipsychotics. Methods Antipsychotic-related GM cases were collected in Chengdu Women′s and Children′s Central Hospital. Meanwhile, antipsychotic-related GM literature cases in PubMed, Embase, ScienceDirect, Wanfang, VIP, and CNKI databases up to November 2019 were searched. The age, fertility status, primary mental disease, causative agents, duration of medication, diagnosis and characteristics of breast lumps, serum prolactin level, intervention measures, and prognosis of these patients were collected and analyzed retrospectively. Results A total of 7 clinical patients and 9 literature cases with antipsychotic drug-related GM were collected, and all of them were female, aged 21-55 years, of which 10 patients were never giving birth. They took antipsychotics for 0.5-17.0 years. The causative drugs included risperidone in 8 of the 16 patients. Other antipsychotics included olanzapine, clozapine, sulpiride, aripiprazole, perphenazine, quetiapine, amisulpride, flupentixol and melitracen, and etc. Serum prolactin levels elevated in 12 patients (25.45-84.50-μg/L), were normal in 3 patients, and were not mentioned in 1 patient. Surgical resection was performed in 9 patients. GM were improved significantly in the remaining 7 patients with or without adjusting antipsychotics after receiving oral administration of bromocriptine and/or methylprednisolone. And GM recurred in 1 patient during the followed-up. Conclusion Antipsychotic-related GM may occur in women of any age, regardless of whether they have giving birth. Risperidone is the main antipsychotic drug causing GM.
王涵，田春祥，宁平，李根，梁华. 抗精神病药致肉芽肿性乳腺炎临床病例分析及文献复习[J]. 药物不良反应杂志, 2020, 22(8): 466-470.
Wang Han, Tian Chunxiang, Ning Ping, Li Gen, Liang Hua. Clinical cases analysis and literature review of granulomatous mastitis induced by antipsychotics. Adverse Drug Reactions Journal, 2020, 22(8): 466-470.
