Severe lower gastrointestinal hemorrhage caused by overdose of aspirin without a doctor′s advice
Department of Pharmacy, Qingdao Central Hospital, Shandong Province, Qingdao 266042; Department of Pharmacy, First Affiliated Hospital of Soochou University, Jiangsu Province, Suzhou 215006
Abstract：A 67-year-old female patient took aspirin enteric-coated tablets 100-mg thrice daily orally in order to prevent arteriosclerotic cardiovascular disease without doctor′s advice. After 42 days of medication, the patient developed hematochezia, which was progressively aggravated and finally led to severe hemorrhagic anemia (red blood cell count 1.55×1012/L, hemoglobin 47-g/L) and decreased blood pressure (58/33-mmHg). On the 4th day of bleeding, exploratory laparotomy was performed and colonic hemorrhage was diagnosed. Ligation of the mesenteric artery was performed and the patient′s bleeding stopped. The patient took aspirin by herself at a daily dose exceeding the recommended dose without assessment of benefits and bleeding risks by professional physicians and developed severe lower gastrointestinal hemorrhage, which led to hospitalization and surgical treatment. It was a grade H medication error.
张洁婷，杨海，庄雪梅，于迪. 自服过量阿司匹林致严重下消化道出血[J]. 药物不良反应杂志, 2020, 22(11): 638-639.
Zhang Jieting, Yang Hai, Zhuang Xuemei, Yu Di. Severe lower gastrointestinal hemorrhage caused by overdose of aspirin without a doctor′s advice. Adverse Drug Reactions Journal, 2020, 22(11): 638-639.
