Hematuria induced by ketorolac tromethamine injection in a child
Department of Pharmacy, the People′s Hospital of Pingyi County, Shandong Province, Pingyi 273000, China; Teaching Department of Surgery, Shandong Medical College, Shandong Province, Linyi 276000, China
Abstract：A 2-year-old boy with hydrocele of spermatic cord received an IV infusion of ketorolac tromethamine injection 7-mg after laparoscopic high ligation of bilateral sheath to relieve pain. About 17-hours after the medication, the boy developed gross hematuria. Ultrasonic examination showed blood clots in the bladder. Routine urine analysis showed urine occult blood (++), red blood cells >50 cells per high-power field in urine microscopy, and protein (+++). The boy did not use other drugs in the same period, and hematuria related to ketorolac tromethamine injection was considered. The boy received IV infusions of etamsylate injection 0.5 g once daily and then ceftriaxone sodium for injection 0.5 g once daily successively. After 6 days of treatments, the boy′s gross hematuria disappeared. Routine urine analysis showed urine occult blood (+++), 3 red blood cells per high-power field in urine microscopy, and urine protein (+++). Eleven days later, the re-analysis showed urine occult blood (+), none red blood cell per high-power field in urine microscopy, and urine protein (++). One month later, the re-analysis showed urine occult blood (-) and urine protein (-).
