Abstract：A 61-year-old female patient with depressive disorder was prescribed paroxetine hydrochloride 20-mg orally once each morning, but the patient took the drug thrice daily by mistake. On the 6th day of medication, the patient suddenly fell down. She was unconscious accompanied by limb convulsion, presenting as epileptic attack. Electroencephalogram (EEG) showed a moderate abnormality. The patient had no previous history or family history of epilepsy, the cause of the seizures was considered to be overdose of paroxetine hydrochloride. The drug was taken correctly as prescribed by doctor and magnesium valproate sustained release tablets 0.25 g orally twice daily were added. The patient did not have any further epileptic attack and the EEG recovered to normal.
孙振晓，于相芬. 超量服用盐酸帕罗西汀致癫痫发作[J]. 药物不良反应杂志, 2021, 23(1): 51-52.
Sun Zhenxiao, Yu Xiangfen. Epileptic seizures due to overdose of paroxetine hydrochloride. Adverse Drug Reactions Journal, 2021, 23(1): 51-52.
