Abstract：A 77-year-old female patient was given combined chemotherapy with paclitaxel for injection (albumin bound) and nedaplatin for ovarian malignant tumor with peritoneal metastasis. When paclitaxel for injection (albumin bound) 100-mg dissolved in 0.9% sodium chloride injection 250-ml was given intravenously for the first time, the infusion was not smooth and the drip rate was slow. After stopping infusion, the infusion device was checked and white flocculent sediment above the filter was found. Clinical pharmacists ruled out the possibility of precipitation caused by drug preparation and incompatibility contraindications, and found that the infusion device used by this patient was a precision one (the pore diameter of microporous filter was 5-μm). However, in the drug label of paclitaxel for injection (albumin bound), it was pointed out that "Use of filters with a pore size less than 15-μm may result in blockage of the filter and should not be used." On the second day, a general infusion device (filter with 20-μm pore size) was used for IV infusion of paclitaxel for injection (albumin bound) and the process was smooth and no blockage recurred.
宋佳伟，王璐，陈慧娟，刘丽，王强强，吴炜. 注射用紫杉醇（白蛋白结合型）输液器选择错误致过滤器阻塞[J]. 药物不良反应杂志, 2021, 23(3): 165-166.
Song Jiawei, Wang Lu, Chen Huijuan, Liu Li, Wang Qiangqiang, Wu Wei. Filter blockage caused by wrong selection of paclitaxel for injection (albumin bound) infusion device. Adverse Drug Reactions Journal, 2021, 23(3): 165-166.
