论著
Lui Shumin;Yao Zhuxing;Bai Qingyun;Xu Ying
2006, 8(1): 17-19.
Objective: To observe the effects of different dosages of cocklebur fruit (Fructus Xanthii) on body weight, serum transaminase and hepatic malonaldehyde level of mice. Methods: 60 mice were divided into 4 groups (15 mice each). The three treatment group (low, medium and high dosage) were fed 1.04 g/kg, 5.28 g/kg, 20.8 g/kg dosage of cocklebur fruit powerdered extract (1 g equivalent to 15 g crude drug) daily for 4 weeks respectively, while the control group was administered with physiological saline. The body weight, hepatic malonaldehyde and serum transaminase level were measured every week after drug administration. Results: The weight gain in the treatment groups was less than that in the control group in the first two weeks. The high dosage treatment group showed weight loss in the third week, and all treatment groups showed weight loss in the fourth week. A total increase in body weight of the treatment group was significant lower than that of the control group (P< 0.05 or P<0.01). The level of serum aspartate transaminase in the high dosage treatment group was much higher than that of the control group. The difference was significant (P<0.05). The hepatic malonaldehyde level of the three treatment groups were much higher than that of the control group,the comparison between the high dosage treatment group and the control group P< 0.001, the comparison between the low or medium dosage treatment group and the control group P< 0.05.Conclusion: A harmful effect of cocklebur fruit was found on mice gastro-in- testinal system, including lipid peroxidization in liver.
