Adverse Drug Reactions Journal

2005 Volume 7 Issue 6 Published: 28 December 2005

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综述

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综述
Relationships between mechanism of adverse reactions and structure for fluoro- quinolones

2005, 7(6): 401-407.

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论著

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论著
The tolerance and safety of carvedilol on chronic heart failure patients with chronic renal dysfunction

Luo Leiming;Fan Li;Xue Hao;Yang Xue;Shi Jun;Zhu Bing;Ye Ping

2005, 7(6): 408-411.

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Objective: To estimate the tolerance and safety of carvedilol on chronic heart failure(CHF) patients with chronic renal dysfunction(CRD). Methods: 68 CHF patients with CRD were chosen to receive carvedilol therapy in addition to sufficient anti-heart failure treatment including digitalis ACE inhibitors and diuretics. The carvedilol was given from 6.25 mg to 37.5 mg each day and the course of treatment lasted six months. The tolerance and adverse effects of carvedilol were investigated. Results: Carvedilol is well tolerated for all 68 CHF patients with CRD being under treatment through the end of study. Carvedilol significantly improved cardiac output and renal filter function. 22 patients reached the target dose of 37.5mg/day, and the average dose tolerated by patients was 25.2 mg/day. The incidence of adverse effects occurred in 19 cases most of them were minor and reversible and only 4 of them were serious and needed urgent management. Conclusion: The third generation of beta-blocker carvedilol could improve cardiac and renal function in chronic heart failure patients with chronic renal dysfunction. Moreover it is safe and tolerant.
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论著
Evaluation of the safety of terazosin,tamsulosin and finasteride for benign prostatic hyperplasia

Ye Lm①;Ren Yu①;Li Yi①;Song Hao①;Lj Ningning①;Chu Zhengzheng①;Xiong Ying①;②

2005, 7(6): 411-417.

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Objective: To evaluate the safety of terazosin tamsulosin finasteride and their combination for the treatment of benign prostatic hyperplasia. Methods: Correlative databases websites and medical journals were searched for the randomized clinical trials (RCTs) controlled clinical trials(CCTs) cohort studies and case reports about the serious adverse events available. The quality of the literature was evaluated the data were extracted and meta-analyzed if appropriate or otherwise would be described. Results: Nine RCTs one CCTs and three other studies met the inclusion criteria. The meta-analysis suggested that tamsulosin had a better safety profile than terazosin in the occurrence of dizziness headache orthostatic hypotension and discontinuations due to adverse reactions. There was no statistic difference between terazosin and tamsulosin in the occurrence of other adverse events. By comparison with finasteride terazosin caused more dizziness and there was no statistic difference between terazosin and finasteride in the occurrence of impotence and decreased libido. Tamsulosin and finasteride were compared in only one trial so a meta-analysis could not be done. However the results of this trial indicated that tamsulosin seemed to be safer than finasteride. Two studies compared terazosin and finasteride with their combination and found contradictory conclusions. Conclusion: According to the analysis it is concluded that tamsulosin may have a better safety and acceptability profile than terazosin. There is not enough evidence of finasteride causing more impotence and decreased libido. The safety of tamsulosin and finasteride can not be made definitely because of the insufficiency of information.

不良事件

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Interferon alfa-associated diabetes millitus

2005, 7(6): 417-417.

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调查研究

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调查研究
Investigation of norvancomycin used in surgical patients

Chen Yan;Jin Xue;Nie Lei

2005, 7(6): 418-421.

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Objective: To investigate norvancomycin use in surgical patients and evaluate the rationality and cost of medications. Methods: 253 surgical cases under norvancomycin therapy were collected and analysed retrospectively and at random. Results: Norvancomycin administration could be irrational in many ways, mainly untimely use before operations (97.6%) misuse(92.9%)and overlong use of more than 2 days after operations(88.9%). Norvancomycin was used with other 2-3 other antibiotics simultaneously in 8 cases and even with antagonistic antibiotics in 11 cases. The per case expence of norvancomycin was 1910.32 Yuan and accounted for 30.28% of the total drug expenses in this survey. Conclusion: Norvancomycin is the last choice in curing Gram-positive bacterial infection and its irrational use should be avoided in order to diminish the adverse reactions.
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调查研究
Literature analysis of allergic reactions associated with Yuxingcao injection in 120 cases

Yang Xiaoqing;Yao Hai;Huang Yiming;Liu Fei

2005, 7(6): 421-423.

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Objective: To analyse allergic reactions caused by Yuxingcao injection in clinical practice. Methods: 120 cases with allergy due to Yuxingcao injection were retrieved and analysed from"China Periodicals Database"(1994-2005.1). Results: It was shown that Yuxingcao injection-induced allergy was not related to sex and age of patients but related to route of administration(P < 0.05), intravenous infusion in particular. The main clinical symptoms were cardiac distresss,dyspnea, mental confusion and others,featuring fast start and quick development, and 92.50% of the reactions occurred within 30 minutes after treatment (P < 0.05). Among 120 cases, 37 were anaphylactic shock (accounting for 30.83%) and 23 of them were severe. Conclusion: Immediate hypersensitivity reactions(such as anaphylactic shock) due to Yuxingcao injection should be paid more attention by medical staffs.

安全用药

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安全用药
Adverse effects and precautions of ketamine

2005, 7(6): 424-427.

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安全用药
Ingredients and clinical rational use of Ermiao Pills and Simiao Pills

2005, 7(6): 427-429.

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Cyclophosphamide-induced cerebrovascular spasm

2005, 7(6): 429-429.

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药物滥用

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药物滥用
Drug abuse addiction and dependence from narcotics and psychotropics

2005, 7(6): 430-433.

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病例报告

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病例报告
Sodium valproate-induced severe thrombocytopenia and fibrinogenopnian

2005, 7(6): 433-433.

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中毒救治

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中毒救治
Management of poisoning caused by Xueshan Hongjingtian oral solution in a child

2005, 7(6): 434-435.

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中毒救治
Clinical analysis of neurological disorders caused by compound diphenoxylate tablets in younger children

2005, 7(6): 435-436.

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病例报告

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Oral cyclophosphamide-associated acute liver impairment

2005, 7(6): 436-436.

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专题讲座

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专题讲座
Drug-induced neurological disorders (4)

2005, 7(6): 445-449.

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病例报告

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病例报告
Heshouwu-related severe liver impairment

2005, 7(6): 449-449.

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病例报告
Severe of gastrointestinal disorders and jaundice secondary to levofloxacin administration

2005, 7(6): 450-450.

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病例报告
Limbs myasthenia and hypokalmia caused by intravenous infusion of lincomycin

2005, 7(6): 450-451.

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病例报告
Severe drug eruption induced by ofloxacin

2005, 7(6): 451-452.

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病例报告
Creatine kinase increase after intravenous infusion of vancomycin hydrochloride

2005, 7(6): 452-453.

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病例报告
Levofloxacin-induced exfoliative dermatitis

2005, 7(6): 453-453.

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病例报告
Acute drug-induced hepatitis attributed to the use of fleroxacin

2005, 7(6): 453-454.

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病例报告
Rigor and high fever caused by aceglutamide injection

2005, 7(6): 454-454.

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病例报告
Severe asthmatic attacks following diazepam injection in a child

2005, 7(6): 455-455.

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病例报告
Epidermolysis bullosa in connection with cefalexin and trimethoprim capsules

2005, 7(6): 455-456.

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Rifampicin-induced influenza-like syndrome and numbness of lower limbs

2005, 7(6): 456-456.

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监测交流

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监测交流
Intervention of clinical irrational drug use by PASS

2005, 7(6): 457-458.

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监测交流
Quality assessment of 222 ADR reports

2005, 7(6): 458-460.

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监测交流
Analysis of quimolones-induced neurological adverse reactions of the elderly

2005, 7(6): 460-461.

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不良事件

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不良事件
Erythema multiforme in association with Shuanghuanglian oral solution in a childy

2005, 7(6): 462-462.

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不良事件
Severe allergy during intravenous infusion of Aidi

2005, 7(6): 462-463.

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不良事件
Bronchial asthma due to Zhenghonghuayou liniment

2005, 7(6): 463-463.

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不良事件
Zhibitwo-induced hyposexuality : 3 case reports

2005, 7(6): 463-463.

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不良事件
Pain in gastrocnemius attributed to the use of azithromycin

2005, 7(6): 463-464.

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不良事件
Severe urticaria caused by hepatitis B vaccine

2005, 7(6): 464-464.

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不良事件
Yusingcao injection-induced anaphylactic death showing laryngeal edema and visceral congestion at autopsy

2005, 7(6): 464-465.

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不良事件
Hiccup during treatment with dexamethasone

2005, 7(6): 465-465.

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Anaphylactic shock in association with enoxacin injection

2005, 7(6): 465-465.

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国外信息

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国外信息
Adverse reactions of new cholesterol absorption inbibitor ezetimibe

2005, 7(6): 466-468.

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病例报告

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病例报告
Itraconazole-associated acute allergic interstitial nephritis

2005, 7(6): 471-471.

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2005 Volume 7 Issue 6 Published: 28 December 2005

综述

论著

不良事件

调查研究

安全用药

不良事件

药物滥用

病例报告

中毒救治

病例报告

专题讲座

病例报告

监测交流

不良事件

国外信息

病例报告