调查研究
Feng Xia;Zhang Chunmei;Zhong Yi
2005, 7(5): 332-335.
Objective: To investigate the clinical manifestions and causative factors of adverse reactions following sufentanil injection in order to safe use of the drug. Methods: 173 cases treated with sufentanil in our hospital were retrospectively studied and the results were statistically analysed by SPSS (version12). Results: Of 173 patients, the adverse events were found in 33 cases with incidence 19.08%, and adverse reactions were found in 17 cases with incidence 9.83%. The main adverse reactions were cardiovascular and gastrointestinal reactions . The adverse reactions had no relation with sex, age of patients and combination use of drugs(P > 0.05), and they had relation with administration and dosage of sufentanil(P < 0.01). Most adverse reactions occurred 2- 6 hours after administration. Conclusion:Clinical adverse reactions caused by sufentanil should be mastered for safe use of the drug.