调查研究
Qi Wenjie;Wang Hong;Ren Aimin;Zhang Lixia;Zhang Shuwen
2005, 7(4): 252-256.
Objective:To investigate the involed pathogens and their drug resistance in patients with acute infection. Methods: A retrospective study was performed of clinical data of the pathogens prevalence and the resistance to antimicrobial drugs in 85 patients with acute infection admitted to Beijing Friendship Hospital between 2002-2004. Results: Gram-negative bacteria were the main cause of infection, accounting for up to 50.0%, followed by Gram-positive bacteria(26.8%), and fungi (23.2%). Predominant Gram-negative bacteria included Enterobacter sp, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter. The Gram-positive bacteria included Staphylococci and Enterococci. Candida was the main cause of fungal infection. Vancomycin was active against Gram-positive cocci, which were resistante to penicillin in 66-100% of reslstance rate. A higher resistance to ampicillin was found among common Gram-negative bacteria, which were, however, lower resistance to tienam and sulperazone. After the treatment for 10 days , the resistance to antimicrobial drugs increased significantly in S. aureus, Escherichia coli and Enterobacter cloacae. Conclusion: Closely monitoring the pathogens prevalence , the resistance to antimicrobial drugs, and following rational antimicrobial therapy would provide an efficient measure for reducing the emergence of drug-resistant pathogens.