Adverse Drug Reactions Journal

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综述

Proton pump inhibitors safety and rational use

2005, 7(2): 81-90.

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病例报告

Cardiac arrest and death in connection with intravenous iopromide

2005, 7(2): 90-90.

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论著

Plasma-potassium concentration affected by benazepril and spironolactone combination in patients with chronic heart failure

Shi Jun;Luo Leiming;yang Xue;Xue Hao;Liu Guoshu

2005, 7(2): 91-94.

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Objective: To study plasma-potassiun concentration affected by benazepril and spironotactone combination in CHF patients with or without chronic renal failure. Methods: 60 CHF patients without CRF(CHF/ CRF^-)and 24 CHF patients with CRF( CHF/CRF⁺)were chosen to receive benazepril or benazepril plus spironolactone therapy. The changes of plasma- potassium concentration and incidence of hyperkalaemia were followed up and investigated. Results: The plasma- potassium concentration was increased after two weeks therapy in all patients(p < 0.01). Compared with single benazepril therapy benazepril and spironolactone combination induced significant increase of plasma-potassium concentration in patients with CHF/CRF⁺ (P< 0.01) but not in those with CHF/CRF^-(P > 0.05). With the same combination therapy the plasma-potassium concentration was higher in patients with CHF/CRF+ than in those with CHF/CRF^- (P< 0.01). Although incidence of hyperkalaemia was 33% in CHF/CRF⁺ patients receiving the combination therapy, differences compared with the other were not of significance. Conclusion: Application of benazepril and spironolactone combinatim is safe for CHF patients without CRF, and the incidence of hyperkalaemia is lower. But in those with CRF, there is a risk of hyperkalaemia. The cautions should be given to those receiving combination therapy to prevent them from hyperkalaemia.

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不良事件

Levofloxacin-induced bullosa eruption

2005, 7(2): 94-94.

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不良事件

Diarrhea caused by ambroxol tablets

2005, 7(2): 94-94.

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调查研究

Investigation of influenza vaccine safety

Liang Yan;Zhang Haiyan;Lu Yunlan;Cui Yimin

2005, 7(2): 95-97.

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Objective: To investigate the safety of influenza vaccine. Methods: After administration of influenza vaccine in 1325 individuals in 2003 the incidence type and outcome of adverse reactions (AR) were analysed. Results: The AR incidence was 55.32% (733 / 1325) including local reactions (77.76%570 / 733) with duration median of 3 days and systemic reactions (42.43%311 / 733) with duration median of 2 days. Moderate and mild AR were in a majority the latter in particular(57.57%). Persons with AR were all cured (431) or self-cured (302). Conclusion: Influenza vaccine is safer in consideration of AR nature of mildness short duration and easy recovery.

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调查研究

Literature review of adverse reactions caused by Ciwujia injection in 103 cases

Xing Yuqi;Zhang Yuqiu;Shi Na

2005, 7(2): 97-100.

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Objective: To investigate adverse reactions caused by Ciwujia injection. Methods:Literature was retrieved from domestic medical journals 1994-2003, and 103 cases with the adverse effects in 75 papers were analysed. Results: The adverse effects were mainly anaphylactic shock (33.98%), then systemic reactions and disorders in skin and respiratory system. Conclusion: Allergy is the common adverse reaction to Ciwujai injection and close attention should be paid to it in clinical practice.

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调查研究

Literature analysis of allergic reactions associated with Shuanghuanglian in 111 cases

Zhang Yuewen①;Shi Lifeng②;Li Jianping①;Wang Shoudong①;Fang Xiaoyan①;Bai Ming①;Chang Liming③

2005, 7(2): 100-103.

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Objective: To analysis allergic reactions caused by Shuanghuanglian in clinical practice. Methods: 111 cases with allergy due to Shuanghuanglian were collected and analysed from "China Periodicals Net"(2000.12-2004.3). Results: It was shown that Shuanghuanglian-induced allergy was not related to sex and age of patients but related to route of admi-nistration. As for the types of allergy 67 were anaphylactic shock (accounting for 60 %) 61 skin reactions (55 %) 14 the other reactions (13%) and 31 suffered more than one symptoms of allergy. Shuanghuanglian-induced allergy occurred from one minute to three days after administration of the drug and 97 cases (87%) developed the symptoms of allergy in the period of treatment. Conclusion: Immediate hypersensitivity reaction (such as anaphylactic shock)is the common type of allergy associated with Shuanghuanglian.

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调查研究

Clinical investigation of adverse reactions induced by fat emulsion injection in 25 cases

Shi Huiqing;Zhang Lina;Zhong Yi

2005, 7(2): 103-105.

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Objective: To investigate the factors of adverse reactions induced by fat emulsion injection. Methods: 25 reports of adverse raactions due to fat emulsion injection at our hospital in 2003 were retrospectively analysed. Results: Fever was the main clinical manifestation. The reactions were related to age of patients and concentration of the drug but not related to gender of patients. Conclusion: Health professionals should pay attention to the use of fat emulsion so as to reduce the occurrence of adverse effects.

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病例报告

Gastrointestinal hemorrhage associated with warfarin and metronidazole combination

2005, 7(2): 105-105.

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安全用药

Clinical manifestations and causative drugs of drug-induced myopathy

2005, 7(2): 106-108.

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安全用药

Withdrawal syndromes produced by drugs used in psychiatric disordersi

2005, 7(2): 108-111.

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安全用药

Blood products safety and rational use used in psyc)

2005, 7(2): 111-113.

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不良事件

Anaphylactic shock attributed to intravenous infusion of zedoary turmeric oil and glucose injection

2005, 7(2): 113-113.

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中毒救治

Aconite toxicity and poisoning management

2005, 7(2): 114-115.

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药物评介

Montelukast-induced adverse reactions and safe use

2005, 7(2): 116-117.

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专题讲座

Drug-induced hematological disorders (6)

2005, 7(2): 125-127.

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病例报告

Transient aplastic anemia associated with allopurinol

2005, 7(2): 128-129.

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A 78-year-old man got lumbago, edema for 9 years and cough, expectoration for 30 years, and was hospitalized with progressive severity of the symptoms for 5 days. He was diagnosed as coronary heart disease,chronic bronchitis, diabetes, and treated with anti-infection and symptomatic therapy. Several days later, he received allopurinol 100mg twice daily by mouth,because of high serum concentrations of uric acid. The patient developed chill, hyperpyrexia and fatigue after 9 consecutive days of administration. Physical examination revealed a temperature of 39.6℃ and lab findings included WBC 0.8×10⁹/L with neutrophil 0.4. Aplastic anemia was approved on bone marrow puncture. Allopurinol was withdrawn immediately and the the symptoms were resolved.

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病例报告

Hepatorenal impairment caused by sodium aescinate

2005, 7(2): 129-129.

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A 51-year-old man was hospitalized with severe pain on waist and limitation of movement for one hour. He was diagnosed as compression fracture on lumbar vertebrae 1, and treated with intravenous infusion of sodium aescinate 10mg daily. The patient developed fever, sweat, nausea, fatigue, anorexia, yellowing of sclera and the skin after receiving the medication. Physical examination showed tenderness on right upper abdomen and percussion pain on both renal areas. Lab findings showed ALT 753U/L, T-Bil 80.1μmol / L and BUN 19.44mmo / L. It was considered to be drug-induced hepatorenal impairment. Sodium aescinate was then withdrawn. 10 days later his conditions were returned to normal.

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病例报告

Dermato-joint allergic purpura following cefaclor treatment in a child

2005, 7(2): 129-130.

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A 7-year-old boy was presented with abdominal pain for 3 days, and developed swelling and pain on both knee-joints and restriction of motion after taking cefaclor 0.25g 3 times. It was considered to be associated with drug allergy. The boy had a history of allergic responses to penicillin ,so cefaclor was discontinued. Physical examination showed a lot of petechial rash on both lower limbs with symmetric distribution. He was diagnosed as dermato-joint allergic purpura and given therapy with corticosteroid etc. 3 days later, his symptoms lessened and resolved gradually.

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病例报告

Transient disorientation attributed to the use of zolpidem

2005, 7(2): 130-131.

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An 82-year-old man was presented with dizziness for 30 years and progressive severity of nausea for one month. He was diagnosed as hypertension. He stopped taking antihypertensive drugs one year before the present hospitalization. The man was given zolpidem 10mg, once per night by mouth due to insomnia. 20 minutes after the second administration, the patient developed abnormal behavior and incorrect response. Physical examination showed inabilities of orientation, calculation and memory, mild stiff neck and positive Hoffmann sign. The man had no family history of mental disorders in the past. The above symptoms did not recur after withdrawal of zolpidem. It seems reasonable to link his symptoms to zolpidem treatment.

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病例报告

Mental disorders after taking overdose of Xin Suxiao Ganmao tablets

2005, 7(2): 131-132.

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病例报告

Shock associated with intravenous infusion of levofloxacin: 2 case reports

2005, 7(2): 132-132.

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病例报告