Adverse Drug Reactions Journal

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综述

Advances in clinical presentation and pathogenesis of aristolochic acid nephropathy

2004, 6(4): 217-225.

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病例报告

Abdominal angina associated with ceftriaxone sodium

2004, 6(4): 225-225.

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论著

Effects of carvedilol on vascular endothelial function and insulin resistance in hypertensive patients with diabetes mellitus

Xue Hao①;Luo Leiming②; Peng Yingxin①;Liu Guoshu②

2004, 6(4): 226-228.

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Objective: To investigate the effects of carvedilol on vascular endothelial function and insulin resistance in hypertensive patients with type 2 diabetes mellitus. Methods: Following discontinuation of any cardiovascular drugs for 2 weeks, 41 patients with arterial hypertension and diabetes mellitus were divided randomly into carvedilol group(21cases) and metoprolol group(20 cases). Before treatment and after 6 months of treatment, fasting glucose and insulin were measured. Insulin sensitivity index was calculated. Reactive congestion and nitroglycerin-induced dilation of the brachial artery were assayed with high-resolution ultrasound. Results:After 6 months of treatment, carvedilol significantly reduced blood pressure. Fasting insulin was reduced and insulin sensitivity index was increased significantly. Reactive congestion and nitroglycerin-induced vasodilatation were improved. And after 6 months of treatment with metoprolol, fasting blood sugar and insulin was increased and insulin sensitivity index was reduced slightly. Reactive congestion and nitroglycerin-induced vasodilatation were not improved. Conclusion: Carvedilol effectively reduced blood pressure and improved insulin resistance, endothelial-dependent vasodilatation and endothelial-independent vasodilatation in hypertensive patients with type 2 diabetes mellitus.

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调查研究

Study on rifampicin-induced acute interstitial nephritis

Yang Liming①;Jiang Yah①;Wang Liran②;Jin Fuhua①;Wang Xicha0①;Zhang Rui③

2004, 6(4): 229-231.

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Objective: To study the treatment of rifampicin-induced acute interstitial nephritis(AIN). Methods: 29 cases with rifampicin-induced AIN, aged 25-59, were treated with individualized hemodialysis (or peritoneal dialysis) and drugs. Results: After the above-mentioned treatment, all patients improved considerably, that is, gradually symptoms resolved,urinary outflow increased and normalized, serum creatinine and blood urea nitrogen were lowered from 2091.3μmol/L and 55 mmol/L to normal respectively. Conclusion: The treatment with dialysis and drugs combination shows satisfactory effects on rifampicin-induced AIN.

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调查研究

Analysis of hepatitis cases induced by traditional Chinese patent medicines

Guo Lizhu

2004, 6(4): 231-235.

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Objective: To investigate the agents, pathogenesis and management of liver impairment induced by traditional Chinese patent medicines (TCPM). Methods:103 hospitalized cases with TCPM-induced hepatitis in 1991-2003 were retrospectively analysed. Results: TCPM-induced hepatitis was mainly due to drugs for osteoarthropathy, followed by drugs for dermatoses. And clinical presentation was mostly hepatocellular damage and cholestasis. Improvement and recovery were achieved most part of patients treated with drugs for liver disorders. Conclusion: Hepatitis can be induced by TCPM, especially those for osteoarthropathy and dermatoses, which may suggest the hepatotoxicity or prescription incompatibility in the above drugs.

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调查研究

Adverse reactions caused by beta-lactam antibiotics:analysis of 133 cases

Zhao Chunjing①;Jiang Chengli①;Cao Yali②

2004, 6(4): 235-239.

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Objective: To analyse the characterization of adverse reactions to beta-lactam antibiotics for rational drug use. Methods: 133 case reports of ADR associated with beta-lactam antibiotics were collected and analysed by Chongqing ADR Monitoring Center. Results: 26 drugs were involved in 133 ADR case reports, including ceftriaxone sodium (37 cases,constituting 27.82% of all cases), benzylpenicillin(20 cases,15.04%)and cefotaxime sodium(12 cases, 9.02%). There were 18 cases of type A reaction and 115 cases of type B reaction, among them allergic reactions in 98 cases(73.68%). Serious reactions amounted to 15 cases, of which 1 case died. Conclusion: Rational use of beta-lactam antibiotics should be emphasized in the clinical practice in order to prevent and reduce the occurrence of ADRs.

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病例报告

Allergic reactions to traditional Chinese medicines in 7 patients with pollen hypersensitivity

2004, 6(4): 239-239.

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安全用药

Nephrotoxicity of nonsteroid anti-inflammatory drugs

2004, 6(4): 240-243.

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安全用药

Drug-induced serotonin syndrome and its treatment

2004, 6(4): 243-246.

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安全用药

Uncommon adverse reactions to amoxicillin/clavulanate potassium

2004, 6(4): 246-248.

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安全用药

Adverse effects and precautions of docetaxel

2004, 6(4): 248-250.

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病例报告

Abdominal pain and diarrhea caused by intravenous infusion of houttuynine in a child

2004, 6(4): 250-250.

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中毒救治

The management of fructus xanthii poisoning

2004, 6(4): 251-252.

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不良事件

Hyperplasia of mammary glands secondary to glipizide

2004, 6(4): 252-252.

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病例报告

Frequent atrial premature beats secondary to intravenous infusion of fleabane

2004, 6(4): 253-253.

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A 72-year-old man was hospitalized with pathological changes of both hip joints. Day 6 after op-eration of hip joint replacement, the patient was treated with intravenous infusion of fleabane. He devel-oped headache, palpitation and dyspnea during the infusion, then the agent was discontinued immediately. Oxygen was administrated. ECG showed sinus arrhythmia and frequent atrial premature beats of 4-5/min. It was considered in association with fleabane. 30 minutes later, the symptoms including headache and palpitation lessened, respiration was stable and ECG showed normality. Headache and palpitation resolved 1 hour later.

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病例报告

Death in connection with lincomycin therapy

2004, 6(4): 253-254.

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病例报告

Tiopronin-associated chill and hyperpyrexia

2004, 6(4): 254-255.

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A 40-year-old man was hospitalized with anorexia, weakness and yellow urine for 3 days after 1 month of antituberculosis therapy.Physical examination showed mild yellow sclera and secondary pulmonary tuberculosis. He was diagnosed as tuberculosis and drug-induced hepalitis. The patient was treated with antituberculosis drugs,drugs for liver disorders, and intravenous infusion of tiopronin 0.2g/day. His appetite was improved, while weakness,yellow urine and sclera were partially resolved. Several days later, the patient developed chill and hyperpyrexia(39.5℃). The temperature was gradually returned to normality and chill was resolved 10 minutes after treatment of promethazine and aminopyrine. When the patient was given tiopronin the next day, chill and hyperpyrexia recurred. It was considered that the symptoms were associated with tiopronin, since no adverse reactions occured after tiopronin was discontinued.

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病例报告

Ampicillin-associated multiple organ impairment

2004, 6(4): 255-256.

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病例报告

Cholestatic hepatitis following combined use of Xiaojin pill and Rupixiao tablet

2004, 6(4): 256-257.

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病例报告