Adverse Drug Reactions Journal

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调查研究

Investigation of adverse reactions to glucocorticoids in 460 SARS patients

Wang Yuqin①;Wen Manhua①;Chang Ming②;Ding Qinghua②;Zeng Yan①;Meng Li①;Wu Xiaoguang①;Tang Zhe①;Niu Guangsheng③

2004, 6(2): 78-82.

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Objective : To investigate adverse reactions in SARS patients treated with glucocorticoids. Method:Clinical data of460cases with SARS in Xuanwu Hospital and China-Japa n Friendship Hospital were retrospectively analysed using SPSS statistical softw are.Results:344of460cases were under glucocorticoids therapy(GT),resu lting in decreased serum potassium(17.2%)and serum calcium(32.0%) ,increased blood sugar(30.5%),psychogeny(20.1%),bacterial infec tion(53.5%),mycotic infection(14.8%),and liver impairment (60 .2%).The incidence of adverse reactions were much higher in GT group of≥3 20mg daily than group of<320mg daily,and in GT group than in non-GT gr oup.Conclusion:Glucocorti-coids should only be used with great caution in SAR S patients,that is,paying more attention to existing indications and fol-lowi ng adverse effects,taking the drug doses as low as possible,and high doses may be only used for life-threatening case.

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Kidney damage associated with low-dose of enteric-coated aspirin tablets in 16 patients

Zhang Qiuxia;Wang Yuling

2004, 6(2): 82-84.

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Object iv e:To investigate kidney damage caused by low-dose of enteric-coated aspirin t ablets.Method:The outcomes of600patients tak ing aspirin(50～75mg dai ly)were retrospectively analysed from January1995to August2003in our h ospital.Results:Kid ney damage occurred in16of600cases.Its frequen cy wa s related to age of patients,dosage and treatment duration of aspirin.And imp aired renal function was returned to normal gradually when aspirin was withdrawn in them.Conclusion:Prolonged oral admi nist ration of aspirin in low-dose can cause kidney damage and ordinary exam ination of urine and renal function is suggested,especially for the elderly.

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Liver disorders induced by traditional Ch inese patent medicines in 41 cases

Liang Bing;Zhou Guangyou;Yin Ling;Zhang Han

2004, 6(2): 85-87.

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Objective:To investigate the liver disorders in connection with tr ad itional Chinese patent medicines(TCPM).Method:During1998-2000,liv er disorders caused by TCPM were analysed in41patients with different disease s.Results:Icterus,symptoms of alimentary system and abnormal liver function occured in all patients.Withdrawal of TCPM and start of liver-protective thera py made liver function normalized within1-4weeks.Conclusion:Hepatic reactio ns to TCPM were re-ported increasingly and great importance should be attached to it.

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调查研究

Analysis of prescriptions for 1207 inpatients

Guo Daihong①;Liu Guiyang①;Wei Xin②;Liu Jing②;Wang Xiang②

2004, 6(2): 88-91.

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Objective:To understand current use of drugs for inpatients.Met ho d:Prescription Automatic Screening System(PASS)was used for investigation of possible drug interactions.Results:7314prescriptions of1207inpatients were analysed,and739drugs were involved in total,6drugs per prescription o n average.The frequency of drug administration was as follows in order:drugs regulating water and electrolytes,cardiovascular drugs,antimicrobials,gastro-intestinal drugs,hormones,drugs affecting the blood,vitamins and minerals. There were drug-drug interactions in204cases and drug-food ones in235cas es.The incidence of adverse reactions were3%,22.8%and42.62%respec tively for1-4,5-9and over10drugs in combined use.Conclusion:In order to avoid adverse reactions the prescribing should follow the principle of ration al drug use,and the number of the drugs should be prescribed as few as possible .

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病例报告

Anaphylactic reaction during intravenous infusion of water-soluble vitamin compound

2004, 6(2): 91-91.

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病例报告

Cerebrolysin-induced leukemoid reaction and multi-organ dysfunction:2 case report

2004, 6(2): 113-114.

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病例报告