Adverse Drug Reactions Journal

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病例报告

Scarlatiniform erythema during allopurinol therapy

2004, 6(1): 8-8.

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调查研究

Drug-induced renal impairment:clinical and pathological analysis of 25 cases

Wang Yuhua;Huang Caihong

2004, 6(1): 9-11.

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Objective: To observe the clinical manifestations and pathological chan ges of drug-induced renal impairment. Method: 25 cases with drug-induced renal i mpairment were analysed retrospectively, who were confirmed clinically and patho logically. Results: 25 cases included both acute (20) and chronic (5) renal fail ure. In former there were acute renal tubular necrosis (13) and acute interstiti al nephritis (7). And their outcomes were deaths (2), recovered (15) and chronic (3). In latter all 5 cases were chronic interstitial nephritis, resulting in 3 deaths. The renal impairment related to dosage and couse of treatment for follow ing drugs: gentamicin, contrast media, cisplatin, methotrexate, NSAIDs, longdanx ieganwan, while no such relations were found in ampicillin, cefazolin, ciproflox acin. Conclusion: Dosage and course of the above-mentioned drugs for treatment should be cautioned, together with consideration of patients' age and physical condition, such as dehydration, hypoproteinemia, diabetes, nephrosis, the elderl y and children in particular.

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Diagnosis and treatment of 53 patients with mannitol-induced osmotic nephrosis

Yang Liming①;Lu Ping①; Wang Liran②; Wang Qipeng①; Guo HongYan①; Yang Yanping①

2004, 6(1): 11-14.

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Objective: To investigate the effects of both dialysis and drug treatme nt on mannitol-induced osmotic nephrosis. Method: 53 cases aged 25-81 with manni tol-induced osmotic nephrosis were treated with a combination therapy of drugs and individualized hemodialysis/ peritoneal dialysis. Results: After treatment , much improvement occured in 48 cases, that is, gradual disappearance of sympto ms, normalized urinary output, serum creatinine and blood urea nitrogen decreas ed from 1934.8ìmol/L and 49 mmol/L to normal level respectively. Conclusion: P roper dialysis and drugs therapy could produce a satisfactory effect on mannitol-induced osmotic nephrosis.

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Vaccination reactions reporting system and the analysis of reports

Ma Fubao;Diao Liandong;Tang Fenyang

2004, 6(1): 14-17.

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Objective: To make assessment of reactions after vaccination. Method: T he vaccination reactions reporting system was established in Jiangsu province in 2002. Results: 273 cases of vaccination reactions were reported in 2002 and the major clinical symptoms were systemic rash (51.28%) and local reactions (16.12% ). The reporting peak was in April and May. 13 vaccines caused unwanted effects and Japanese B encephalitis inactivated vaccine and DPT were responsible for 70. 33% and 20.15% of the total cases respectively. Conclusion: To strengthen the va ccination reactions reporting system is beneficial to implementing the planned i mmunization programme.

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Anaphylactic shock caused by lincomycin injection:analysis of 61 cases from literature

Zhang Enjuan;Ge Qin;Jiang Min

2004, 6(1): 17-19.

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Objective: To investigate the occurrence of anaphylactic shock induced by lincomycin injection. Method: The reports of lincomycin-induced shock were re trieved and analysed, totaling 44 papers on 46 domestic medical journals of 199 4-2002. Results: Anaphylactic shock occurred in 61 cases, including 8 deaths. Co nclusion: Anaphylactic shock due to lincomycin should be paid more attention to , being dangerous enough to cause death if treated improperly and untimely.

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病例报告

Anaphylactic shock after urokinase treatment

2004, 6(1): 35-35.

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Puerarin-induced severe hemolytic reaction:2 case reports

2004, 6(1): 40-41.

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病例报告