Adverse Drug Reactions Journal

Select

不良事件

Allergic reaction associated with use of fluconazole

2003, 5(6): 370-370.

Abstract ( ) PDF ( )

Select

调查研究

The preventive effects of silibinin on the cardiac toxicity caused by doxorubicin

Wang Huimin①;Lian Hongxing①;Xu Jijun①;Li Haishan②;Chen Xinzhi③

2003, 5(6): 371-374.

Abstract ( ) PDF ( )

Objective: To study the alleviative effects of silibinin(SB), one of the flavonoid chemicals, on the cardiac toxicity to mouse, which was caused by doxorubicin(Dox). Method: Compared with the Kunming mice treated with Dox, the content changes of blood serum creatine kinase(CK), aspartate aminotransferase (AST)and cardiac MDA were determined in mice by administration of both Dox and SB. Results: SB could antagnize the activity increasing of CK and AST which was caused by Dox, and significantly lower the level of MDA in heart. Conclusion: SB can reduce the formation of lipid peroxiation, thus alleviating cardiac toxicity markedly.

Select

调查研究

Adverse effects associated with corticosteroids therapy in 57 SARS cases

He Rong;Liu Zhuang;Duan Xuefei

2003, 5(6): 374-377.

Abstract ( ) PDF ( )

Objective: To observe adverse effects in SARS patients receiving corticosteroids. Method: 98 SARS cases were treated with or without corticosteroids, that is, divided into treatment group(57 cases) and control group(41). The former was then subgrouped under three different doses of the drug:<160mg/day(16 cases), ≥320mg/day(6) and in-between(35); and under different administration duration: <20 days(19 cases), ≥20 days(38). The adverse effects were compared between corticosteroids groups and control group. Results: In corticosteroids groups and control group, hypopotassemia was 43.9% and 26.8%, elevation of blood-glucose concentration was 45.6% and 22.0%, secondary infections were 31.6% and 14.6% respectively. Fever recurred markedly in the former(38.6%) during a gradual reduction in dosage while 17.1% in the latter. Thoracic x-ray manifestations showed more severe inflammation in the former (21.1%) than in the latter (7.3%). And occurrence rates of unwanted reactions were positively related with the doses and duration of treatment among corticosterodis groups. Conclusion: Corticosteroids treatment of SARS infection may result in hypopotassemia, elevation of blood glucose and more secondary infections. When its dosage reduces gradually, fever would recurred.

Select

调查研究

Treatment effects and adverse reactions of antihypertensive drugs in elderly outpatients

Nie Yingjuan;Qian Yuanyu;Ren Suqin;Yang Xiaoqiu;Guo Daihong;Meng Qingyi

2003, 5(6): 377-380.

Abstract ( ) PDF ( )

Objective: To investigate the situation of antihypertensive drugs' use and their adverse effects for elderly outpatients. Method: Information of antihypertensive drugs' use and the resulting adverse effects in 955 elderly cases with primary hypertension in outpatient department was collected by questionnaire visit and physical examination. Results: The most common drugs, which the patients would use to decrease blood pressure, were nifedipine delayed-release tablet(69.8%), nifedipine(30.8%) and metoprolol(27.5%), and then followed by indapamide, enalapril, terazosin, benazepril and captopril. Only nearly half of patients' blood pressure were under control in normal range (systolic pressure <140mmHg, dialectic pressure <90mmHg). The most common adverse effects were lower limb edema for calcium antagonists, hypokalemia for diuretics, cough for ACEI (angiotensin-converting enzyme inhibitors), bradycardia for βreceptor blockers and postural hypotension for αreceptor blockers. Conclusion: Antihypertensive drugs were not satisfactory for control of blood pressure and the adverse reactions were common in elderly outpatients.

Select

病例报告

Acute generalized eruptive pustulosis secondary to clindamycin use

2003, 5(6): 392-392.

Abstract ( ) PDF ( )

Select

病例报告

Elevated blood pressure after treatment with bifendate

2003, 5(6): 395-395.

Abstract ( ) PDF ( )

Select

病例报告