调查研究
CAI Haodong;MA Xiuyun;CUI Zhenyu
2003, 5(5): 301-305.
Objective:To evaluate the long-term efficacy and appropriate course of lamivudine for hepatitis B virus infec-tion.Method:Adults who were HBsAg,HBeAg,and HBV DNA positive were enrolled in this study.Lamivudine was given100mg daily for three years(156weeks)and its effects on HBV DNA,HBeAg,ALT and HBV mutation was observed.Re -sults:Lamivudine had an obvious inhibiting effect on HBV DNA,and was effective for keeping ALT normal.At the second year,virus mutation occurred in39.8%of patients,partly with rebound of HBV DNA level.The effects of lamivudine were associated with ALT and HBV DNA level of patients before treatment.It was safe with good tolerance and its adverse reac-tions were mild.Conclusion:Lamivudine is good for inhibiting replication of virus and maintenance of normal ALT.Patients with positive HBeAg and HBV DNA,lower DNA level and higher ALT level are the best candidates of lamivudine treatment.Its long-term effects for HBV infection are related to HBV mutation.