2003 Volume 5 Issue 2 Published: 28 April 2003

  

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调查研究

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  调查研究

  Adverse reactions of levofloxacin injection and related factors

  Liang Yan;Lu Yunlan

  2003, 5(2): 77-80.

  Abstract ( ) PDF ( )

  Objective;To investigate the adverse reactions of levofloxacin injection, including the frequency, manifestationsand the related factors. Method; A multicentre prospective study of levofloxacin injection was carried out in eight hospitals in Beijing between October 2000 and September 2001, and the collected data were analysed. Results- The adverse drug reactions occurred in 143 of 4437 inpatients (3.22%) , with 58.04% of mild type. The clinical manifestations most often involved the gastro-intestinal tract and skin. Conclusion: The adverse effects of levofloxacin injection showed generally low frequency and mild symptoms, which were associated with the dose, duration,interactions of levofloxacin administration. It should be used with care in elderly patients and in allergic subjects.
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  Clinical observation of adverse reactions to thalidomide used for multiple myeloma

  Yan Jinsong*;Guo Ping

  2003, 5(2): 81-83.

  Abstract ( ) PDF ( )

  Objective;To observe the side-effects of thalidomide used for multiple myeloma. Method:Thalidomide-induced unwanted effects were analysed in 32 inpatients with multiple myeloma. Results; The occurrence rate of adverse reactions was 94% in all, 87.5% in alimentary system, 84.4% in neuropsychic system,and the others included sinus bradycardia, escape rhythm, drug fever, skin rashes, edema, etc. Conclusion; Thalidomide could cause gastro-intestinal and neuropsychic disturbances, which would disappear or relieve with discontinuation of administration or reduction of dose.
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  Adverse reactions and safety of clindamycin

  Huang Xiang;Li Jun;Zheng Lina;Li Yong

  2003, 5(2): 83-87.

  Abstract ( ) PDF ( )

  Objective;To evaluate the side-effects induced by clindamycin and its safety in clinical practice. Method:According to organ/system types recommended by WHO, the adverse reactions of clindamycin in 248 cases were classified. Results; 15 organs/systems were involved and the commonest ADRs were damages of skin and its appendages, digestive system, central and peripheral nervous system. Conclusion; Clindamycin should be used with caution in patients with a history of hypersensitivity. There is a potential danger of significant diarrhoea, hematuria and respiratory depression mainly because of drug interactions.