2003 Volume 5 Issue 1 Published: 28 February 2003

  

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调查研究

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  调查研究

  Clinical observation of ramosetron's effects on prevention of gastrointenstinal reactions induced by anti-cancer drugs

  Gao Wenbin;Yin Liangwei;Qi Xiaojun;Wang Huaijin

  2003, 5(1): 5-8.

  Abstract ( ) PDF ( )

  Objective; To observe ramosetron's effects on prevention of gastrointestinal reactions induced by cisplatin and doxorubicin. Method: 156 cancer patients with an indication of intra-arterial chemotherapy were randomly divided into two groups, 78 cases each receiving cisplatin (≥50mg/m2) and doxorubicin (≥40 mg/m2) respectively in the therapy scheme. 15-30 minutes before chemotherapy group one was given with ramosetron 0.3mg and group two granisetron 3mg (plus dexam-ethasone10mg) by intravenous injection. The patients were monitored during the first three days for effects and unwanted reactions of the two drugs. Results; Compared with granisetron, ramosetron showed the same therapeutic effects on anorexia, nausea and vomiting. And no significant differences of adverse reactions were found in the two groups, such as headache, carebaria, thirst, constipation, diarrhea, hot flushes, fatigue, drowsiness, insommia and dysphoria. Conclusion; As a new generation of 5-HT3-receptor antagonist, ramosetron has proved to be safely used for its antiemetic properties in clinical practice.
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  Analysis of adverse reactions in 127 cases

  Su Wanzeng;Wang Qing;Wang Minru;Wang Xinmei;Zhang Yongmei

  2003, 5(1): 8-11.

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  Objective: To analyse the clinical manifestations and management of drug-induced adverse reactions. Method: The inpatients of 1989-2001 were retrospected, who developed unwanted reactions during treatment courses. Results.- In 127 cases of adverse reactions cardiovascular drug-induced ones accounted for 77 cases (60.63%),followed by hormones (22 cases, 17.32%), antibiotics ( [leases, 8.66%), antineoplastic drugs (3 cases, 2.36%) and others (Meases, 11.02%). Among them were 48 cases of severe reactions (37.79%), resulting in 6 deaths (4.72%) . Serious reactions included anaphylaxis, laryngeal edema, ventricular tachycardia, angioneurotic edema and acute renal failure. Conclusion: Adverse reactions can be associated with many drugs, mostly with cardiovascular drugs.
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  Drug rash misdiagnosed as eruptive contagious diseases in 18 cases

  Jiang Yuyong

  2003, 5(1): 11-13.

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  Objective: To analyze the causes of drug rash misdiagnosed as eruptive contagious diseases. Method; 18 inpa-tients misdiagnosed as eruptive contagious diseases were reviewed in our hospital in last eight years. Results; 1.Drug rash was supposed to be measles by mistake in the first place. 2.Antibacterials and nonsteroidal anti-inflammatory drugs were the most common causes of drug rash. 3.Doctors might be careless in consultation and examination although the diseases shared some presentations in clinic. Conclusion; Diagnosis of drug rash should be improved so as to reduce the misdiagnosis that would have been avoided.
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  Analysis of adverse reactions to cardiovascular drugs in 739 cases

  Jiang Shuang;Wang Xiaobo;Xi Ronggang;Yang Dongcai

  2003, 5(1): 13-17.

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  Objective: To specify clinical characteristics and causes of adverse reactions to cardiovascular drugs. Method: 739 adverse reactions to cardiovascular drugs were collected and analyzed from domestic articles in 1998-2001. Results: Adverse reactions to cardiovascular drugs occurred in the body's seven systems, with respiratory system in the highest proportion(29.8%) . Six groups of drugs were involed and ACEI was the main one for causing ADR (230 cases) . As for ADR intensity, severe reactions were showed in 46 cases, among them 15 deaths. Most of ADR were caused by oral administration(65.5%) and in age of 51 and upwards (78.9%). Conclusion:The occurrence of adverse reactions to cardiovascular drugs was related to drugs' pharmacology, route of administraction, interactions and patients' age, individual difference.