2002 Volume 4 Issue 6 Published: 28 December 2002

  

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调查研究

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  调查研究

  Adverse reactions caused by anti-infective drugs:Analysis of 513 cases

  Zhao Huanyu;Li Jiajing

  2002, 4(6): 361-364.

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  Objective: To survey the adverse reactions caused by anti-infective drugs for their safe use in clinical practice. Method: ADR cases were analysed in Beijing Tongren Hospital during the last eight years. Results: 513 ADR cases were associated with 72 anti-infective drags, commonly aminoglycosides(114 cases, 22.22%), penicillins (107 cases, 20.86%), cephalosporins (97 cases, 18.91%) and quinolones(86 cases, 16.76%). Most of ADR were found in the skin and its appendages, nervous system and digestive system. Conclusion: Rational use of anti-infective drugs should be taken to decrease the occurrence of adverse reactions.
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  A review of drag-induced liver damage in 509 cases

  Wu Yuanshan;Zheng Qiku;Li Yueling;Bi Qili;Huang Zuojun

  2002, 4(6): 364-368.

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  Objective: To investigate the drug-induced liver damage in recent years. Method: Literature was retrieved from CBMdisc 1990-2001. Results: Antituberculous agents, traditional Chinese medicines and immunosuppressants were the most common drugs responsible for liver damage(LD). The risk of LD might be increased in patients by concomitant administration of potentially hepatotox-ic drugs. In the cases of renal transplantation, immunosuppressants would result in acute liver failure, the major death cause of LD. Conclusion: Care should be taken for LD caused by the above drugs, with liver function monitoring in renal recipients in particular.
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  142 ADR cases in association with traditional Chinese medicines

  Zhou Jian;Guo Daihong;He Peihong

  2002, 4(6): 368-371.

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  Objective: To discuss the adverse reactions caused by traditional Chinese medicines(TCM). Method: 142 ADR reports from PLA ADR Database 2001 were used for statistical analysis. Results: The ADR frequency was increased with involement of many kinds of TCM, mostly by injection. Conclusion: Caution should be advised in administering TCM to patients because of the annual rise of its adverse reactions.
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  调查研究

  Analysis of 18 cases with hematuria caused by intravenous drip of cefradine

  Tan Zhiping;Wang Huichuan;Sha Furong

  2002, 4(6): 371-373.

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  Objective:To investigate the association of hematuria with the intravenous drip of cefradine. Method: 18 cases with hematuria due to cefradine were received and analysed at the emergency department of our hospital from July 2000 to July 2001. Results: 1. The majority of patients with hematuria were young adults. 2. Hematuria occurred almost within an hour after intravenous drip of cefradine. 3. Hematuria could be related with dosage and purity of cefradine, and individual hypersensitivity. Conclusion: Much attention should be paid to cefradine for intravenous drip in order to reduce frequency of hematuria.