2002 Volume 4 Issue 5 Published: 28 October 2002

  

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调查研究

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  调查研究

  Clinical implication of long R - R intervals by digoxin treatment of atrial fibrillation in the elderly

  Li Yanhan;Luo Leiming;Zhang Ling

  2002, 4(5): 297-298.

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  Objective: To investigate the influence of digoxin treatment on R - R intervals in the elderly with continuous atrial fibrillation. Method: Concentration of plasma digoxin, frequency of long R - R intervals and pattern of atrioventricular conduction in response to synchronized cardioversion were observed in 84 cases after administration of digoxin. Results: Small doses of digoxin could decrease the ventricular rate and long R- R intervals appeared in 37 cases, accounting for 44 percent. No cases were with second-degree atrioventricular block after the cardioversion. Conclusion: Small doses of digoxin showed the safe and effective control over the ventricular rate. The long R- R intervals may be associated with increased atrioventricular junctional concealed conduction induced by digoxin' s parasympathominetic effect rather than its overdose use. So it would not be considered as an indicator of the withdrawal of the drug.
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  Analysis of drug eruption in 173 cases

  Luan Hong;Li Linfeng

  2002, 4(5): 298-301.

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  Objective: To clarify the drug- induced eruption and its relation to fever and hepatorenal damage. Method: 173 inpa-tients who developed eruption from January 1996 to December 2000 were investigated. Results: 23 drugs were suspected of inducing eruption, including penicillins responsible for 86 cases (49.7% ), antipyretic- analgesics for 17 cases (9.8% ), sulfonamides for 15 cases (8.7% ), and traditional Chinese patent medicines for 11 cases (6.4% ) . The drug eruption could be divided into three patterns: exanthem, erythema multiforme and urticaria. Eruption was combined with fever or hepatorenal damage in 29.5% and 44.5% of 173 cases respectively. Conclusion: Penicillins seem to be the main factor in association with drug eruption, followed by antipyretic- analgesics, sulfonamides and traditional Chinese patent medicines.
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  Antiepileptic drug hypersensitive syndrome: clinical analysis of 11 cases

  Cheng Xiaohong;Zhong Xin;Liu Cuizhong

  2002, 4(5): 301-303.

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  Objective: To study the diagnosis, treatment and prognosis of antiepileptic drug hypersensitive syndrome (DHSS) . Method: 11 children with DHSS due to antiepileptic drugs (AED) during hospitalization from May 1995 to April 2002 were enrolled and followed up for the clinical data collected and analysed. Results: Fever, eruption, mucosal lesion, desquamation and pigmentation appeared in all patients. Moreover, liver damage occurred in 7 cases. Lymphadenovarix, heart and kidney disorders each occurred in 4. Marrow involvement was found in 2 and Stevens - Johnson syndrome in 1. All cases were given corticosteroid and clinic relief was observed thereafter. Followed up for 6 months, seven of 11 cases showed reversible internal organ dysfunction. Skin pigmentation still existed though. Seven cases with indication for the continuation of AED therapy switched phenytoin, carbamazepine and phenobarbi-tal to sodium valproate (5 cases) and topiramate (2), with no resulting hypersensitivity and seizure. Conclusion: DHSS usually occurs within 1 to 6 weeks after initiation of AED therapy, typically presents with fever, eruption and internal organ involvement. The prognosis is quite well if suspected drugs discontinue and the expectant treatment starts.