调查研究
Xiong Fengzhen
2002, 4(3): 154-156.
Objective: To understand ADR induced by calcium antagonists. Method: Medical literature was retrieved from Chinese Pharmaceutical Abstracts (1992-1999) including 113 articles of 30 journals for ADR occurrence after calcium antagonist treatment. Results: Among 7 calcium antagonists causing ADR in 166 cases nifedipine came first (62 cases, accounting for 37.35% ), followed by flunarizine (51 cases, 30.72%) and nimodipine (20 cases, 12.05%) .ADR of 48 cases (28.92%) located in central nervous system, then 26 cases (15.66% ) in cardiovascular system, and 21 cases (12.65% ) in skin. Except for 2 deaths, 164 cases all recovered after discontinuation of the calcium antagonists and start of the expectant treatment .112 cases ( 67.5 % ) were the elderly over 50. Conclusion: Most of elderly patients suffering from cardio - cerebro - vascular diseases were susceptible to calcium antagonists and should be put in close attention clinically with the adjusted doses.