2002 Volume 4 Issue 1 Published: 28 February 2002
  

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    调查研究

  • 调查研究
    Wang Yong;Peng Chenghong
    2002, 4(1): 9-11.
    Abstract ( ) PDF ( )
    Objective: To discuss the safe dosage of octreotide given through hepatic artery. Method: 18 cases who accepted radical excision of liver cancer were given drugs through hepatic artery pump. The first day's dosages were octreotide 200μg, suspension of CDDP and lipiodol 18ml (CDDP 40mg and superliquefied lipiodol 10ml), and the following day only octreotide 200fig. The remedy repeated every 4-8 weeks. Their vital signs, general condition, and routine laboratory examination were observed before and after the administration of drugs. Results: The adverse reactions were mostly symptoms of alimentary tract: nausea and vomiting (66.67%), anorexia (77.78%), constipation (27.78%), abdominal distention (72.22%), pain in right hypochondria! region (61.11%), facial hectic fever (88.89%, among them 55.56 % suffered hectic fever of whole body), palpitation (22.22%), hepatic function disorder (77.78%), thrombocytopenia and decreased PT (5.56%), transient fever (16.67%), paralytic ileus (5.56%) . Any transparent problems of myocardium and renal function didn't be found. Conclusion: 1.Administration of octreotide 200fμg through hepatic artery is safe. 2.Facial hectic fever or whole body hectic fever seems to be the only and transient body reaction to octreotide given through artery. 3. It is needed to be further confirmed whether octreotide is helpful to the prevention of relapse and metastasis after radical excision of liver cancer.
  • 调查研究
    He Suiping;Liang Jianhua;An Yuan
    2002, 4(1): 11-13.
    Abstract ( ) PDF ( )
    Objective: To analyze adverse drug reactions and its related factors in 94 elderly patients. Method: ADR reporting forms over years of our hospital were collected and reviewed. Results: 1 .Patients with ADR over 60 years old accounted for 39.5% of all ADR forms, occuring more in male than in female. 2.Clinical manifestations of dermoreaction and nervous system reaction were demonstrated, ranking the first and second respectively on the ADR order list. 3. Most drugs of inducing ADR were for the treatment of cardiac cerebral - vascular diseases and infectious diseases. Conclusion: Occurrence of ADR in the elderly is in the close relation with their original diseases and the combined use of drugs.