调查研究
Wang Yong;Peng Chenghong
2002, 4(1): 9-11.
Objective: To discuss the safe dosage of octreotide given through hepatic artery. Method: 18 cases who accepted radical excision of liver cancer were given drugs through hepatic artery pump. The first day's dosages were octreotide 200μg, suspension of CDDP and lipiodol 18ml (CDDP 40mg and superliquefied lipiodol 10ml), and the following day only octreotide 200fig. The remedy repeated every 4-8 weeks. Their vital signs, general condition, and routine laboratory examination were observed before and after the administration of drugs. Results: The adverse reactions were mostly symptoms of alimentary tract: nausea and vomiting (66.67%), anorexia (77.78%), constipation (27.78%), abdominal distention (72.22%), pain in right hypochondria! region (61.11%), facial hectic fever (88.89%, among them 55.56 % suffered hectic fever of whole body), palpitation (22.22%), hepatic function disorder (77.78%), thrombocytopenia and decreased PT (5.56%), transient fever (16.67%), paralytic ileus (5.56%) . Any transparent problems of myocardium and renal function didn't be found. Conclusion: 1.Administration of octreotide 200fμg through hepatic artery is safe. 2.Facial hectic fever or whole body hectic fever seems to be the only and transient body reaction to octreotide given through artery. 3. It is needed to be further confirmed whether octreotide is helpful to the prevention of relapse and metastasis after radical excision of liver cancer.