调查研究
Wang Rui;Li Naxin;Dong Jingyuan
2001, 3(4): 226-229.
Objective: To investigate the general pattern and characteristics of ADRs to cephalosporins and to guide rational drug use.Methods: 386 cases developing drug adverse reactions to cephalosporins ,reported in Chinese literature in the past 10 years, were analysed.Results:There were 45 cases of type A reaction and 341 cases of type B reaction, mostly with allergic reactions (35.49%)and urinary lesion (29.02%). Serious ADRs amounted to 93 cases, of which,7died. Among cephalosporins, ADRs of cefoperazone (97cases), cefradine (78 cases) and cefazolin (69 cases) accounted for 25.13% , 20.21 % and 17.88% , respectively.Conclusion:Rational use of cephalosporins should be strengthened in the clinical practice in order to prevent and reduce the occurence of ADRs.