2000 Volume 2 Issue 1 Published: 28 March 2000

  

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调查研究

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  调查研究

  Adverse reactions to Zhuangguguanjie Wan and cause analysis

  Cheng Jinghua;Cai Haodong

  2000, 2(1): 15-19.

  Abstract ( ) PDF ( )

  Objective: To approach the clinical manifestations and pathogenesis of adverse reactions caused by Zhuangguguanjie Wan (ZW), a ready-prepared Chinese medicine. Methods: 156 ZW-induced ADR cases in 1992-1998 were collected and reviewed from CBM, Beijing Centre for ADR Monitoring and Beijing Ditan Hospital. Results: ZW is generally for the aged and the most common manifestation is live damage characterized by cholesta-sis, which would be related with improper pattern identification, individual differences and toxicity of some ingredients in ZW. Conclusion: ZW administration needs liver function tested regularly because liver damage might be produced. It is suggested that ZW formula be readjusted.
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  Liver damage caused by Zhuangguguanjie Wan and cost analysis

  Zhou Ying;zheng Guifeng

  2000, 2(1): 20-23.

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  Objective: To analyze the liver damage caused by Zhuangguguanjie Wan for providing information about rational use of the drug. Methods: Liver damage caused by Zhuangguguanjie Wan in our hospital in the last seven years was reviewed in order to analyze its incidence, time of occurrence, clinical characteristics and cost. Results: Most cases were before 1996 and symptoms appeared after 48 days of taking medicine on average. The patients' ALT were 451065 U/L, T-BIL were 21.3376mol/L. The average time they were in hospital was 39.44 days and the average cost was 5605.36 yuan. Conclusion: Drug administration authorities should strengthen the management of package inserts and drug advertisement and the patient should be regularly tested for liver function when using it.
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  Diagnosis and emergency treatment of drug-induced non-cardiogenic pulmonary edema

  Jin Weiqiu;WuPenglan;YangChunyan

  2000, 2(1): 23-25.

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  Objective: To improve the understanding of drug-induced non-cardiogenic pulmonary edema (DINCPE). Methods: The clinical manifestations of 9 cases with DINCPE were analyzed and its diagnosis and e-mergency treatment discussed. Results: The high cure rate of DINCPE was observed if treatment began at early stage. However, its early diagnosis remained low. Conclusion: Physicians should be familiar with and think of DINCPE when the pulmonary edema is refractory to the traditional inotropic and diuretic therapy , with the corresponding treatment at once.
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  Investigation of adverse reactions caused by Tripterygium Wilfordii in patients with glomerular diseases

  Li Hong;Zhong Jiming;Zhou Haiyang;Fan Xingzhong

  2000, 2(1): 25-27.

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  Objective: To give an opinion of using the drug by summarizing adverse reactions of Tripterygium Wilfordii (TW). Methods: Adverse reactions caused by TW were analysed in 82 patients with glomerular diseases. Results: TW may cause headache and dizziness, leukopenia, gonadal toxicity, etc. The patients mostly recovered from adverse reactions by making adjustments in both dose and course of TW and adding relevant treatment. Con- elusion: A reasonable regimen of TW contributes to improving its effects and decreasing its adverse reactions.
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  A review of adverse reactions to quinolones in 410 cases

  Pan Qiaoyi;Wang Lei;Yah Shufeng

  2000, 2(1): 28-30.

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  Objective: To review the adverse reactions induced by quinolones and make safety assessment of the drugs on the market. Methods: Clinical reports on ADR of quinolones, published during the last five years, were collected and analysed by means of literature metrology. Results: In accordance with the incidence of ADR nofloxacin ranked the first, followed by ciprofloxacin, pipemidic acid, pefloxacin, ofloxacin and enoxacin. Various clinical manifestations were involved, mostly allergic reactions and neurological symptoms. Conclusion: Physician s attention should be drawn to ADR surveillance and rational medication.
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  A servey of 165 inpatients with drug-induced diseases

  Yao Linqing;Fang Juanjuan

  2000, 2(1): 31-34.

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  Objective: To find out the causes, incidence and resulting risks of drug-induced diseases. Methods: 165 patients with drug-induced diseases were admitted to hospital during Jan. 1994Oct. 1999 and their data analysed. Results: The increasing incidence of drug-induced diseases was demonstrated because of the non-standard and irrational drug administration. The causing medications in proper order were antimicrobial agents, antipyretic-analgesics and Chinese medicine. Conclusion: The drug-induced diseases can be reduced through some measures taken, such as drug-use guidance, knowledge updating among medical personnel and so on.