1999 Volume 1 Issue 2 Published: 28 September 1999

  

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调查研究

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  调查研究

  Analysis of adverse reactions caused by Qingkailing injection

  Cai Haodong

  1999, 1(2): 92-97.

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  Objective: To analyze the causes of the adverse reactions induced by Qingkailtng injection and research the ways of prevention and treatment. Methods: This article summarized 136 cases of the adverse reactions caused by Qingkailing injection in recent years, analysed the category, the clinical characteristics and causes of the adverse reactions induced by Qingkailing injection. Results: The major adverse effects of Qingkailing injection were allergic reaction type I , and were related to the allergic history and CNS diseases of the patient, diluted concentration of the drug, and other drugs combined with Qingkailing injection. Conclusion: The components and formula of Qingkailing injection should be studied in order to reduce the adverse reactions.
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  Etiology and clinical manifestation of drug-induced hepatitis in 36 cases.

  Huang Huiyi

  1999, 1(2): 97-99.

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  Objective: To promote the clinical level on diagnosis and therapy of drug-induced hepatitis. Methods: According to the medical history, treatment, clinical symptoms, liver function tests, etiological signs and effects of the drug withdrawal, a comprehensive diagnosis was made for the patients admitted to the hospital from 1994 to 1998 due to suffering from viral hepatitis, and eventually a confirmed diagnosis was made that 36 patients among them were suffered from the drug-induced hepatitis. Results: In 36 cases of drug-induced hepatitis, the traditional Chinese medicines accounted for 15 (41.7%) antituberculotics 8 (22.2%), antibiotics 4 (11.1%), sul-fonamides 1 (2. 78%), and sex hormones, nonsteroidal antiinflammatory drugs, antidiabetics, antineoplastics accounted for 2 (5.56%) separately. 35 of 36 drug-induced hepaiitis cases were a-cutic, and only one case was chronic. Conclusion; the attention should be paid to drug choice, dosage and course of treatment for the patients, especially for the patients with hepatorenal insufficiency, the ADR monitoring should be strengthened, and organic function test should be made regularly in orde to prevent the occurrence of drug-induced hepatitis
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  Investigiation of hematuria induced by drugs

  Fang Juaniuan;Li xuqin

  1999, 1(2): 99-101.

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  Objective: To investigation ADR information on hematuria. Methods: To collect ADR cases of hema-turia from Chinese Pharmaceutical Abstract 1994 1998 and make an analysis. Results: In five years, there were 273 cases associated with 51 kinds of westeren medicines and traditional Chinese medicines. Among them 152 cases were induced by the compound diclofenac tablets, accounting for 55.4% . Conclusion: Great attention should be paid to drug-induced hematuria. The formulation of compound diclofenac tablets should be reevaluated.
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  Clinical analysis of nasoseptal perforation caused by beclometasone nasal spray

  Long Ling

  1999, 1(2): 102-103.

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  Objective: To make a follow-up observation of patients with nasoseptal perforation caused by beclometa-sone nasal spray, and put forward preventive measures. Methods: 178 cases of inpatients having applied more than 2 canisters of the drug from 1996 to 1999 were continually observe with rhinoscope for 36 months, and the pathological process of the nasal septum was clinically analyzed. Results: In the 178 cases, there were 12 cases (6.74% ) of mucosal ischemia of the nasal septum, 6 cases (3.37%) of thinned mucosa of nasal septum, 3 cases (1.69% ) of nasal septum mucosal defect, and 5 cases (2.81 % ) of nasal septum perforation. Conclusion: Operate strictly in accordance with the directions, and change the methods for holding the canister to spray the drug into nose; the drug is contraindicated or used with great care for patients before or after nasal septum correction is performed; monthly examination of nasal septum is necessary to prevent perforation for patients using the drug continually.
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  Liver injury through antituberculosis therapy and counter measures

  Ma Guoer

  1999, 1(2): 104-105.

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  Objective: To study the measures for the management of liver injury through antituberculosis treatment. Methods: An increase in aspartate aminotransferase (AST), ranging from 2-6 times the upper limit of the normal (ULN) was recorded in 18 patients. The former therapy was continued fully in 13 patients (AST 2×ULN4 × ULN), and a modified therapy (rifapentine instead of rifampicin) was reintroduced in the other 5 patients (AST 4×ULN6XULN). At the same time, all 18 patients were treated with drugs for liver protection. Results: Treatment was finished successfully in 17 patients. Only one old male patient who had a relapse didn' t finish the treatment because of nausea, bad appetite and jaundice. Conclusions: In spite of an increase in AST level to approximately 6×ULN during antituberculosis therapy, the therapy can be continued in full in most cases and the drugs for liver protection are necessary at the same time.