1999 Volume 1 Issue 1 Published: 28 June 1999
  

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    调查研究

  • 调查研究
    Wang Ting;Fang Juanjuan
    1999, 1(1): 22-25.
    Abstract ( ) PDF ( )
    Objective: To analyse the adverse drug reactions induced by antiinfective drugs. Methods: Reported cases of adverse drug reactions related to antiinfective drugs were collected from Chinese Pharmaceutical Abstracts (1994September, 1998), and arranged in order according to the number of cases for analysing. Results: Penicillins, quinolones and cephalosporins were in the first three places; and serious adverse drug reactions amounted to 535 cases, chief among the reactions were allergic shocks and functional damage to liver and kidney. Conclusion: Rational use of antiinfective drugs should be strengthened in the clinical practice in order to prevent and reduce the occurence of adverse drug reactions.
  • 调查研究
    He Suiping;Zhen Jiancun;Ma Zhenzi
    1999, 1(1): 25-27.
    Abstract ( ) PDF ( )
    objective: To understand the relationship between digoxin toxicity and serum digoxin concentration. Methods: The criterion for diagnosis of digoxm toxicity was established. The serum digoxin concentration was measured by fluorescence polarization immunoassay. Results: 31 of 213 patients receiving digoxin were intoxicated. The incidence of toxicity was 14.5% . Conclusion: The occurence of digoxin toxicity is close related to serum digoxin levels, and the risk of digoxin toxicity is increased with the increase of serum digoxin concentration.
  • 调查研究
    Chen Yifan;Cai Haodong
    1999, 1(1): 28-32.
    Abstract ( ) PDF ( )
    Objective: To study the pathogenesis , prevention and management of the liver damage caused by tra-dional Chinese medicines on analysis of cases with liver damage. Methods: This article summarized 427 cases of liver damage caused by traditional Chinese medicines in the last fifteen years and surveyed incidence of liver damage caused by traditional Chinese medicines, distribution of primary diseases, and clinical characteristics. Results: Liver damage cases induced by traditional Chinese medicines were on the increase year by year , amounted to 32.6% in all cases of the drug-induced liver damage. Those traditional Chinese medicines used to treat osteoarthropathy, kidney diseases and skin diseases induced liver damage more often. Zhuanggu Guanjie Wan , Tripterygium wilfordii Hook. f., and Dioscorea bulbifera L. were the most major medicines inducing liver damage. The clinical characteristics and the pathogenesis of liver damage caused by different medicine were varient. Conclusion: Ratio...更多nal use of traditional Chinese medicines and study of their hepatotoxicity should be strengthened further in clinical practice .
  • 调查研究
    Li Zili;Shi Shushan;Jiang Jinwe;Wang Renrun;Li Fang
    1999, 1(1): 33-35.
    Abstract ( ) PDF ( )
    Objective: To analyse ostconecrosis induced by glucocorticoids in the clinical practice, and provide basis for early prevention , diagnosis and treatment. Methods: 128 cases of osteonecrosis were induced by glucocorticoids treatment during the 10 years between 1986 and 1995, and the aspects of age, sex, course of diseases, primary diseases, dose of glucocorticoids, and early clinical manifestation were analysed. Results: The incidence of osteonecrosis was lower in doses normally than in doses abnormally, and the incidence was higher in long treatment course than in short treatment course. Conclusion: Rational use of glucocorticoids and early prevention can reduce the incidence of osteonecrosis.
  • 调查研究
    CAI Haodong
    1999, 1(1): 36-40.
    Abstract ( ) PDF ( )
    Objective: To analyse the causes of the adverse reactions induced by Shuanghuanglian and to study the way of their prevention and treatment. Methods: This article summarized 179 cases of the adverse reactions caused by shuanghuanglian in recent years, and analysed the classification, clinical characteristics and causes of the adverse reactions induced by Shuanghuanglian . Results: The adverse reactions of Shuanghuanglian were related to the quality of the preparation, the application of the drug and the individual factors. Conclusion: To pay great attention to the adverse reactions of shuanghuanglian .